Histopathological Features And Outcomes Of Biliary Atresia Patients Surviving With Their Native Livers

Background and Aim: Biliary atresia (BA) is described as a progressive fibrosing obstructive cholangiopathy of both intra extrahepatic bile ducts. Portoenterostomy (PE) the mainstay in initial management BA with variable long-term outcomes complications. Objective to analyse clinical histological parameters patients post-successful PE. Methods: Clinical details after successful PE were recorded. Changes histology pre- post-PE compared individual patients. Results: A total 16 included study. The median age was 4 years (1-12 years). at 77 days. During follow-up, all had preserved liver function tests (LFT) bilirubin direct 1.52mg/dl 0.61mg/dl respectively. All maintained synthetic functions albumin 3.93g/dL prothrombin time index 92.5%. Almost 70% them esophageal varix 47% having small varix. In comparison or before PE, biopsies showed lesser degrees ductular reaction, portal inflammation cholestasis. Interestingly, none progression degree fibrosis while 6 regression 3 showing hepatic repair complex. Conclusion: Timely still remains key intervention slowing disease progression. Our study highlighted possible appearance complex few stressing importance timely regular follow-up improving native survival, hence avoiding Liver transplantation.